由于密西西比河的壮阔浩瀚及其历史意义,密西西比河有许多的绰号:
父河(The Father of Waters)
The Gathering of Waters
The Big Muddy (more commonly associated with the Missouri River)
大河(Big River)
老人河(Old Man River)
伟大之河(The Great River)
国家之体(Body of a Nation)
The Mighty Mississippi
El Grande (de Soto)
The Muddy Mississippi
老蓝(Old Blue)
月河(Moon River)